The following list of publications by Lumigen® scientists provides a more thorough understanding of the basic science of chemiluminescent detection and illustrates some of the possibilities for application of Lumigen products to your detection needs.
A.G. Gehring, P.L. Irwin, S.A. Reed, S. Tua, P.E. Andreotti, H. Akhavan-Tafti, R.S. Handley, Enzyme-linked immunomagnetic chemiluminescent detection of Escherichia coli O157:H7. J. Immunol. Meth., 293(1-2), 97-106 (2004).
H. Akhavan-Tafti, W. Xie, R. de Silva, W. Cripps, R. Eickholt, R. Handley, R. Linsky, M. Mazelis, and A.P. Schaap, Robust Chemiluminescent Peroxidase Substrates. In Vitro Diagnostics Technology, May, 2004.
H. Akhavan-Tafti, R. de Silva, R. Eickholt, R. Handley, M. Mazelis, M. Sandison, Characterization of New Fluorescent Peroxidase Substrates. Talanta, 60, 345-54 (2003).
R. Wilson, H. Akhavan-Tafti, B. G. Pollet, R. de Silva, A. P. Schaap, D. J. Schiffrin, Analytical Applications of Electrochemiluminescence. Proc. SPIE - Intl. Soc. Opt. Eng., 4414, 168-177 (2001).
R. Wilson, H. Akhavan-Tafti, R. de Silva, A. P. Schaap, Comparison Between Acridan Ester, Luminol, and Ruthenium Chelate Electrochemiluminescence. Electroanalysis, 13(13), 1083-1092 (2001).
R. Wilson, H. Akhavan-Tafti, R. de Silva, A. P. Schaap, Electrochemiluminescence Determination of 2', 6'-Difluorophenyl 10-methyl-9,10-dihydroacridine-9-carboxylate. Anal. Chem., 73(4), 763-767 (2001).
R. Wilson, H. Akhavan-Tafti, R. de Silva, A. P. Schaap, Electrochemiluminescence of 2', 6'-Difluorophenyl 10-methyl-9,10-dihydroacridine-9-carboxylate. Chem. Commun., 20, 2067-2068 (2000).
H. Akhavan-Tafti, R. de Silva, K. Sugioka, R. Handley, A. P. Schaap, Chemiluminescent Acridan Phosphate Labeling Compounds for Detection in Gels. Luminescence, 16(2), 187-192 (2001).
H. Akhavan-Tafti, R. De Silva, K. Thakur, R. A. Eickholt, C. Chrovian, K. Lauwers, R. S. Handley, S. Siripurapu, C. Endreszl, A. P. Schaap, Recent Advances In Chemiluminescent Enzyme Substrates, in Bioluminescence and Chemiluminescence, J.F. Case, P.J. Herring, B.H. Robison, S.H. Haddock, L.J. Kricka, P.E. Stanley, Eds., John Wiley and Sons, Chichester, 215-218 (2000).
L. V. Reddy, R. de Silva, R. S. Handley, A. P. Schaap, H. Akhavan-Tafti, Sequential Chemiluminescent Detection of Target DNAs without Stripping and Reprobing. BioTechniques, 26(4), 710, 712-4 (1999).
H. Akhavan-Tafti, L. V. Reddy, S. Siripurapu, B. A. Schoenfelner, R.S. Handley, A.P. Schaap, Chemiluminescent Detection of DNA in Low- and Medium-Density Arrays. Clin. Chem., 44(9), 2065-2066 (1998)
R.S. Handley, H. Akhavan-Tafti, A.P. Schaap, Chemiluminescent Detection in High Volume Ligand-Binder Assays. J. Clinical Ligand Assay, 20(4), 302-312 (1998).
H. Akhavan-Tafti, R. de Silva, Z. Arghavani, R. A. Eickholt, R. S. Handley, B. A. Schoenfelner, K. Sugioka, Y. Sugioka, A.P. Schaap, Characterization of Acridancarboxylic Acid Derivatives as Chemiluminescent Peroxidase Substrates. J. Org. Chem., 63(4), 930-937 (1998).
H. Akhavan-Tafti, R. A. Eickholt, Z. Arghavani, A.P. Schaap, A Novel Substitution Process for the Preparation of Alkoxy-, Aryloxy-, and Acyloxy-Substituted 1,2 Dioxetanes. J. Am. Chem. Soc., 119, 245-6 (1997).
L. V. Reddy, H. Akhavan-Tafti, R. de Silva, R. Handley, D. H. Farkas, A.P. Schaap, Novel Chemiluminescent Substrate and Probe Systems for the Identification of CFÆF508 Genotypes. Molecular Diagnosis, 2(2), 113-9 (1997).
H. Akhavan-Tafti, Z. Arghavani, R. de Silva, R. A. Eickholt, R. S. Handley, B. A. Schoenfelner, S. Siripurapu, K. Sugioka, A.P. Schaap, Lumigen APS: New Substrates for the Chemiluminescent Detection of Phosphatase Enzymes, in Bioluminescence and Chemiluminescence Molecular Reporting with Photons, J. W. Hastings, L. Kricka and P. Stanley, Eds., John Wiley and Sons, Chichester, 311-314 (1997).
H. Akhavan-Tafti, Z. Arghavani, R. A. Eickholt, R. S. Handley, M. P. Perkins, K. S. Rashid, A.P. Schaap, Chemiluminescent Haloalkoxy-substituted Dioxetanes: Properties and Applications, in Bioluminescence and Chemiluminescence Molecular Reporting with Photons, J. W. Hastings, L. Kricka and P. Stanley, Eds., John Wiley and Sons, Chichester, 497-500 (1997).
H. Akhavan-Tafti, R. de Silva, Z. Arghavani, R. A. Eickholt, R. S. Handley, B. A. Schoenfelner, A.P. Schaap, Chemiluminescent Detection of Oxidase Enzymes by Peroxidase-Mediated Oxidation of Acridan Compounds, in Bioluminescence and Chemiluminescence Molecular Reporting with Photons, J. W. Hastings, L. Kricka and P. Stanley, Eds., John Wiley and Sons, Chichester, 501-504 (1997).
H. Akhavan-Tafti, K. Sugioka, Z. Arghavani, R. de Silva, R. S. Handley, Y. Sugioka, R. A. Eickholt, M. P. Perkins, A.P. Schaap, Lumigen PS: Chemiluminescent Detection of Horseradish Peroxidase by Enzymatic Generation of Acridinium Esters, Clin. Chem., 41(9), 1368-9 (1995).
H. Akhavan-Tafti, A.P. Schaap, Z. Arghavani, R. de Silva, R. A. Eickholt, R. S. Handley, B. A. Schoenfelner, K. Sugioka and Y. Sugioka, CCD Camera Imaging for the Chemiluminescent Detection of Enzymes using New Ultrasensitive Reagents. J. Biolumin. Chemilumin., 9(3), 155-64 (1994).
H. Akhavan-Tafti, R. de Silva, Z. Arghavani, R. A. Eickholt, R. S. Handley, A.P. Schaap, Lumigen PS: New Chemiluminescent Substrates for the Detection of Horseradish Peroxidase, in Bioluminescence and Chemiluminescence Fundamentals and Applied Aspects, A. Campbell, L. Kricka and P. Stanley, Eds., John Wiley and Sons, Chichester, 199-202 (1994).
H. Akhavan-Tafti, Z. Arghavani, R. de Silva, B. A. Schoenfelner, A.P. Schaap, Applications of Lumigen PS-1 Chemiluminescent Substrate to Immunoassays, in Bioluminescence and Chemiluminescence Fundamentals and Applied Aspects, A. Campbell, L. Kricka and P. Stanley, Eds., John Wiley and Sons, Chichester, 309-312 (1994).
H. Akhavan-Tafti, R. de Silva, Z. Arghavani, K. Sugioka, Y. Sugioka, A.P. Schaap, Blotting Applications of Lumigen PS-3 Chemiluminescent Substrate for Horseradish Peroxidase, in Bioluminescence and Chemiluminescence Fundamentals and Applied Aspects, A. Campbell, L. Kricka and P. Stanley, Eds., John Wiley and Sons, Chichester, 313-316 (1994).
B. A. Schoenfelner, J. Lutz, K. Sugioka, H. Akhavan-Tafti, A.P. Schaap, The Lumigen CCD Camera System: An Economical Cooled CCD Camera System for Chemiluminescent Applications, in Bioluminescence and Chemiluminescence Fundamentals and Applied Aspects, A. Campbell, L. Kricka and P. Stanley, Eds., John Wiley and Sons, Chichester, 633-636 (1994).
H. Akhavan-Tafti, R. S. Handley and A. P. Schaap, "Chemiluminescent Detection Using Alkaline Phosphatase-The Chemistry" in Methods in Nonradioactive Detection, G. C. Howard, Ed., Appleton & Lange, Norwalk, Conn., 70-72 (1993).
H. Akhavan-Tafti, Y.Sugioka, K.Sugioka, R.A. Eickholt, R.S. Handley, Detection of DNA" in Bioluminescence and Chemiluminescence Status Report, A. Szalay, L. Kricka and P. Stanley, Eds., John Wiley and Sons, Chichester, 379-383 (1993).
H. Akhavan-Tafti, K. Sugioka, R.A. Eickholt, R. Krzeczkowski, R.S. Handley, K. S. Rashid, and A. P. Schaap, "Improved Chemilumnescent Western Blotting" in Bioluminescence and Chemiluminescence Status Report, A. Szalay, L. Kricka and P. Stanley, Eds., John Wiley and Sons, Chichester, 312-315 (1993).
H. Akhavan-Tafti, A.P. Schaap, Z. Arghavani, R. de Silva, R. A. Eickholt, C. P. Iscaro, R. S. Handley, K. S. Rashid, B. A. Schoenfelner, K. Sugioka, and Y. Sugioka, Applications of Enhanced Chemiluminescence from Enzyme-Triggerable 1,2-Dioxetanes. The Spectrum, 6(3), 15-19 (1993).
E. G. Beale, E. A. Deeb, R. Handley, H. Akhavan-Tafti, A. P. Schaap, A Rapid and Simple Chemiluminescent Assay for Bacterial ß-Galactosidase. BioTechniques, 12(3), 320 (1992).
K. Tanaka, H. Kato, T. Honda, A. P. Schaap, K. Hirai, K. Kuma, T. Kotani, S, Ohtaki, Chemiluminescent Detection of Antibodies to Thyroid Peroxidase in Serum of Patients with Autoimmune Thyroid Disease. Clin. Chem., 38(6), 1080 (1992).
A. P. Schaap, R. de Silva, H. Akhavan-Tafti, R. S. Handley, Chemical and Enzymatic Triggering of 1,2-Dioxetanes: Structural Effects on Chemiluminescence Efficiency, in Bioluminescence and Chemiluminescence Current Status, P. E. Stanley and L. J. Kricka, Ed., John Wiley and Sons, Chichester, 103-106 (1991).
A. F. Giles, K. J. Booth, J. R. Parker, A. J. Garman, D. T. Garrick, H. Akhavan, A. P. Schaap, Rapid, Simple, Non-Isotopic Probing of Southern Blots for DNA Fingerprinting, in Adv. in Forensic Haemogenetics 3 , H. F. Polesky, W. R. Mayr, Eds., Springer-Verlag, Berlin, 40-2 (1990).
R.S. Handley, H. Akhavan-Tafti, B.P. Giri, S. M. K. Rashid, R. de Silva, M. Gheorghiu and A.P. Schaap, Chemiluminescence from 1,2-Dioxetanes. From Laboratory Novelty to Commercialization. The Spectrum 3(2) 3-7 (1990).
A. P. Schaap and R. S. Handley; "Chemiluminescence", Encyclopedia of Physics, 151-2 (1990).
J. M. Clyne, J. A. Running, H. Akhavan-Tafti, A. P. Schaap, M. S. Urdea, A Rapid Chemiluminescent DNA Hybridization Assay for Detection of Chlamydia Trachomatis. J. Biolumin. Chemilumin., 2, 357-366 (1989).
A. P. Schaap, D. Pollard-Knight, A. C. Simmonds, M. A. W. Brady, H. Akhavan, Sensitive Chemiluminescent Nucleic Acid Detection Using Alkaline Phosphatase Triggered 1,2-Dioxetane. J. Cell Biochem., 13D, 34 (1989).