Lumigen, Inc. - Chemistry that brings meaning to light

Patents

The innovative products of Lumigen have been recognized by the US and foreign patent offices through the granting of numerous patents. Several additional patent applications have gained allowance and will issue in the near future.

Issued U.S. Patents

Detection of Peroxidase
U.S. 7,247,726 Improved Compounds for Generating Chemiluminescence with a Peroxidase, Issued July 24, 2007
U.S. 6,891,057 Compounds for Generating Chemiluminescence with a Peroxidase, Issued May 10, 2005
U.S. 6,872,828 Compounds for Generating Chemiluminescence with a Peroxidase, Issued March 29, 2005
U.S. 6,858,733 Compounds for Generating Chemiluminescence with a Peroxidase, Issued February 22, 2005
U.S. 6,696,569 Compounds for Generating Chemiluminescence with a Peroxidase, Issued February 24, 2004
U.S. 6,410,732 Processes and Synthetic Intermediates for Preparing N-Arylacridancarboxylic Acid Derivatives, Issued June 25, 2002
U.S. 5,922,558 Novel Compositions and Methods for Generating Chemiluminescence with a Peroxidase, Issued July 13, 1998
U.S. 5,750,698 Novel Aryl N-Alkylacridancarboxylate Derivatives Useful For Chemiluminescent Detection, Issued May 12, 1998
U.S. 5,723,295 Novel Method And Kits For Producing Light From An Acridan Compound, Issued March 3, 1998
U.S. 5,670,644 Novel Method And Kits For Producing Light From An Acridan Compound, Issued September 23, 1997
U.S. 5,601,977 Enzyme-Catalyzed Chemiluminescent Detection of Proteins and Nucleic Acids Using Hydroxyaryl Cyclic Diacylhydrazide Compounds, Issued February 11, 1997
U.S. 5,593,845 Aryl N-Alkylacridancarboxylate Derivatives Useful for Chemiluminescent Detection, Issued January 14, 1997
U.S. 5,552,298 Enzyme-Catalyzed Chemiluminescence From Hydroxyaryl Cyclic Diacylhydrazide Compounds, Issued September 3, 1996
U.S. 5,523,212 Novel N-Alkylacridan Carboxyl Derivatives Useful for Chemiluminescent Detection, Issued June 4, 1996
U.S. 5,491,072 Novel N-Alkylacridan Carboxyl Derivatives Useful for Chemiluminescent Detection, Issued February 13, 1996
Detection of Peroxide
U.S. 6,919,463 Signalling Compounds and Methods for Detecting Hydrogen Peroxide, Issued July 19, 2005
U.S. 6,897,036 Fluorescent Detection of Peroxidase Enzymes, Issued May 24, 2005
Chemiluminescent Detection of Hydrolytic Enzymes
U.S. 6,635,437 Compounds, Compositions and Methods for Generating Chemiluminescence with Phosphatase Enzymes, Issued October 21, 2003
U.S. 6,296,787 Compounds, Compositions and Methods for Generating Chemiluminescence with Phosphatase Enzymes, Issued October 2, 2001
U.S. 6,270,695 Compounds, Compositions and Methods for Generating Chemiluminescence with Phosphatase Enzymes, Issued August 7, 2001
U.S. 6,218,137 Compounds, Compositions and Methods for Generating Chemiluminescence with Phosphatase Enzymes, Issued April 17, 2001
U.S. 6,139,782 Compounds, Compositions and Methods for Generating Chemiluminescence with Phosphatase Enzymes, Issued October 31, 2000
U.S. 6,126,870 Novel Chemiluminescent Labeling Compounds, Issued October 3, 2000
U.S. 6,090,571 Compounds, Compositions and Methods for Generating Chemiluminescence with Phosphatase Enzymes, Issued July 18, 2000
U.S. 6,045,991 Compositions and Methods for Generating Red Chemiluminescence, Issued April 4, 2000
U.S. 6,045,727 Compounds, Compositions and Methods for Generating Chemiluminescence with Phosphatase Enzymes, Issued April 4, 2000
U.S. 5,965,736 Compositions and Methods for Generating Red Chemiluminescence, Issued October 12, 1999
U.S. 5,840,963 Chemiluminescent Reactions Between Dihydroxyaromatic Compounds and Heterocyclic Enol Phosphates, Issued November 24, 1998
U.S. 5,772,926 Chemiluminescent Reactions Between Dihydroxyaromatic Compounds and Heterocyclic Enol Phosphates, Issued June 30, 1998
U.S. 5,686,258 Chemiluminescent Detection Of Hydrolytic Enzymes Using An Acridan, Issued November 11, 1997
Chemiluminescent Direct Labels
U.S. 6,126,870 Novel Chemiluminescent Labeling Compounds, Issued October 3, 2000
U.S. 6,017,769 Novel Nonenzymatic Methods of Generating Chemiluminescence from Acridan Alkenes, Issued January 25, 2000
Dioxetane Technology
U.S. 6,410,751 Water Soluble Tri-substituted 1,2-dioxetane Compounds Having Increased Storage Stability, Synthetic Processes And Intermediates, Issued June 25, 2002
U.S. 6,353,129 Water Soluble Tri-substituted 1,2-dioxetane Compounds Having Increased Storage Stability, Synthetic Processes And Intermediates, Issued March 5, 2002
U.S. 6,284,899 Chemiluminescent Dialkyl-Substituted 1,2-Dioxetane Compounds, Methods Of Synthesis And Use, Issued September 4, 2001
U.S. 6,245,928 Water Soluble Tri-substituted 1,2-dioxetane Compounds Having Increased Storage Stability, Synthetic Processes And Intermediates, Issued June 12, 2001
U.S. 6,180,833 Water Soluble Tri-substituted 1,2-dioxetane Compounds Having Increased Storage Stability, Synthetic Processes And Intermediates, Issued January 30, 2001
U.S. 5,936,101 Process for the Preparation of 1,2-Dioxetane Compounds and Novel Sulfur-Substituted 1,2-Dioxetane Compounds as Intermediates, Issued August 10, 1999
U.S. 5,892,064 Chemiluminescent Dialkyl-Substituted 1,2-Dioxetane Compounds, Methods Of Synthesis And Use, Issued April 6, 1999
U.S. 5,886,238 Chemiluminescent Dialkyl-Substituted 1,2-Dioxetane Compounds, Methods Of Synthesis And Use, Issued March 23, 1999
U.S. 5,883,287 Novel Vinyl Sulfide Compounds And A Process For Their Preparation, Issued March 16, 1999
U.S. 5,866,045 Water Soluble Tri-substituted 1,2-Dioxetane Compounds and Assay Compositions Having Increased Storage Stability, Issued February 2, 1999
U.S. 5,804,103 Di-substituted 1,2-Dioxetane Compounds Having Increased Water Solubility and Assay Compositions, Issued July 7, 1998
U.S. 5,777,135 Di-substituted 1,2-Dioxetane Compounds Having Increased Water Solubility and Assay Compositions, Issued July 7, 1998
U.S. 5,721,370 Water Soluble Tri-substituted 1,2-Dioxetane Compounds and Assay Compositions Having Increased Storage Stability, To Issued February 24, 1998
U.S. 5,631,167 Improved Capsule Chemistry Analytical Methods Employing Dioxetane Chemiluminescence, Issued May 20, 1997
U.S. 5,578,253 Chemiluminescent Dialkyl-Substituted 1,2-Dioxetane Compounds, Methods of Synthesis and Use, Issued November 26, 1996
Dual Enzyme Detection
U.S. 6,068,979 Simplified Sequential Chemiluminescent Detection, Issued May 30, 2000
U.S. 5,843,666 Chemiluminescent Detection Methods Using Dual Enzyme-Labeled Binding Partners, Issued December 1, 1998
Chemiluminescence Enhancement
U.S. 5,650,099 Polymeric Phosphonium Salts Providing Enhanced Chemiluminescence from 1,2-Dioxetanes, Issued July 22, 1997
U.S. 5,582,775 Polymeric Phosphonium Salts Providing Enhanced Chemiluminescence From 1,2-Dioxetanes, Issued December 10, 1996
U.S. 5,484,556 Methods and Compositions Providing Enhanced Chemiluminescence from Chemiluminescent Compounds Using Dicationic Surfactants, Issued January 16, 1996
U.S. 5,474,725 Polymeric Phosphonium Salts Providing Enhanced Chemiluminescence from 1,2-Dioxetanes, Issued December 12, 1995
U.S. 5,451,437 Methods and Compositions Providing Enhanced Chemiluminescence from Chemiluminescent Compounds Using Dicationic Surfactants, Issued September 19, 1995
U.S. 5,439,617 Polymeric Phosphonium Salts Providing Enhanced Chemiluminescence from 1,2-Dioxetanes, Issued August 8, 1995
U.S. 5,431,845 Polymeric Phosphonium Salts Providing Enhanced Chemiluminescence from 1,2-Dioxetanes, Issued July 11, 1995
U.S. 5,393,469 Polymeric Phosphonium Salts Providing Enhanced Chemiluminescence from 1,2-Dioxetanes, Issued February 28, 1995
Photosensitizers
U.S. 6,774,249 Uses of Improved Polymer-Supported Photosensitizers in the Generation of Singlet Oxygen, Issued August 10, 2004
U.S. 6,545,102 Improved Polymer-Supported Photosensitizers, Issued April 8, 2003

These patents can be viewed on-line and copies ordered at the IBM Patent Server, MicroPatent PatentWeb and the U.S. Patent Office.